Faculty Members

headshot of Ahyeon Koh

Ahyeon Koh

Associate Professor

Biomedical Engineering
BI 2624

Background

Our research is focused on overcoming obstacles of conventional biosensors. We seek to exploit science and engineering approaches that bring solutions to improve chemical and physical biocompatibilities of biosensors by (1) releasing a therapeutic reagent in a controlled manner from biomedical devices, (2) employing flexible and stretchable platforms with superior biomechanical properties, and (3) developing biomaterials with an emphasis on bio-inspired and bio-mimic technologies. These research areas have great potentials in the developments of ultimate biocompatible bio-sensing systems that intimately integrate with a living system, improve analytical performance of medical devices, and thus provide new technologies to understand human physiology for clinical, point-of-care, and diagnostic/prognostic biomedical applications.

In the Koh Lab, we aim to induce novel biosensor research in the combination of fundamental studies and pioneering engineering efforts that offer multi-disciplinary research opportunities. Our current research focuses on developing breathable biosensors utilized by conventional photolithography, transfer printing and electrospinning, and advancing electrochemical biosensors that function in wearable form while providing a real-time information of biomarkers.

Koh Laboratory

Selected Publications

Koh, A.†; Kang, D.†;Xue, Y.; Lee, S.; Pielak, R. M.; Kim. J.; Hwang, T.; Min, S.; Banks, A.; Bastien, P.; Manco, M. C.; Wang, L.; Ammann, K. R.; Jang, K.-I.; Won, P.; Han, S.; Ghaffari, R.; Slepian, M. J.; Balooch, G.; Huang, Y.; Rogers, J. A. “Soft, Wearable Microfluidic Systems Capable of Capture, Storage, and Colorimetric Sensing of Sweat", In press at Science Translational Medicine

† Equally contributed first author

Koh, A.; Lee, J.; Song, J.; Shin, W. “Simple and Ultrasensitive Chemically Amplified Electrochemical Detection of Ferrocenemethanol On 4-Nitrophenyl Grafted Glassy Carbon Electrode", Journal of Electrochemical Science and Technology, 2016, In Print

Koh, A.†; Gutbrod, S. R.†; Meyers, J. D.†; Lu, C.; Webb, R. C.; Shin, G.; Li, Y.; Kang, S.-K.; Huang, Y.; Efimov, I. R.; Rogers, J. A. “Ultrathin Injectable Sensors of Temperature and Thermal Conductivity for Cardiac Ablation Monitoring" Advanced Healthcare Materials, 2016, 5(3), 373-381 (back cover article)

† Equally contributed first author

Song, J.; Hong, Z.; Koh, A.; Shin, W. “Covalent immobilization of diaphorase in viologen polymer network for highly sensitive detection of NAD+ and NADH" Journal of Electrochemical Science and Technology, 2014, 5(1), 19-22

Koh, A.; Lu, Y.; Schoenfisch, M. H. “Fabrication of nitric oxide-releasing porous polyurethane membranes-coated needle-type implantable glucose biosensors" Analytical Chemistry, 2013, 85(21), 10488-10494

Koh, A.; Carpenter, A. W.; Slomberg, D. L.; Schoenfisch, M. H. “Nitric oxide-releasing silica nanoparticle-doped polyurethane electrospun nanofibers" ACS Applied Materials and Interfaces, 2013, 5(16), 7956-7964

Nichols, S. P.; Koh, A.; Storm, W. L.; Shin, J. H.; Schoenfisch, M. H. “Biocompatible materials for continuous glucose monitoring devices" Chemical Reviews, 2013, 113 (4), 2528-2549

Nichols, S. P.; Koh, A.; Brown, N. L.; Rose, M. B.; Sun, B.; Slomberg, D. L.; Riccio, D. A.; Klitzman, B.; Schoenfisch, M. H. “The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants" Biomaterials, 2012, 33 (27), 6305-6312

Nichols, S. P.; Storm, W. L.; Koh, A.; Schoenfisch, M. H. “Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues" Advanced Drug Delivery Reviews 2012, 64 (12), 1177-1188

Koh, A.;Nichols, S. P.; Schoenfisch, M. H. “Glucose sensor membranes for mitigating the foreign body response" Journal of Diabetes Science and Technology 2011, 5 (5),1052-1059

Koh, A.; Riccio, D. A.; Sun, B.; Carpenter, A. W.; Nichols, S. P.; Schoenfisch, M. H., “Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes" Biosensors and Bioelectronics 2011, 28 (1), 17-24

Relevant Patents

Rogers, J. A.; Koh, A.; Kang, D.; Liu, H.; Huang, X. “Devices and Related Methods for Epidermal Characterization Of Biofluids" publication number WO2016025468 A2, application number PCT/US2015/044638, February 18, 2016

Rogers, J. A.; Efimov, I.; Gutbrod, S.; Xu, L.; Bonifas, R.; Webb, R. C.; Koh, A. “Organ Mounted Electronics" publication number WO2015051085 A2, application number PCT/US2014/058768, April 9, 2015

Education

  • PhD, University of North Carolina at Chapel Hill
  • Post Doctoral, University of Illinois at Urbana-Champaign
  • MS, Sogang University
  • BS, Sogang University

Research Interests

  • Electrochemical biosensors
  • flexible and stretchable sensors
  • biocompatible sensors and materials
  • analytical devices for biomedical applications

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