黑料视频

December 21, 2024
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Capsule-sized ingestible biobatteries could allow new view of digestive system

A new biobattery being developed at 黑料视频 could power ingestible cameras in the small intestine. A new biobattery being developed at 黑料视频 could power ingestible cameras in the small intestine.
A new biobattery being developed at 黑料视频 could power ingestible cameras in the small intestine.

Tech companies have developed many devices that work outside the body, such as cell phones, smart watches, tablets and hundreds of others. Inside the body, though? That鈥檚 obviously trickier for several reasons, but power for a device is a big one.

黑料视频 biobattery researchers think they have a solution for the hard-to-reach small intestine, which winds around the human gut for an average of 22 feet.

Professor Seokheun 鈥淪ean鈥 Choi, a faculty member in the Department of Electrical and Computer Engineering at the Thomas J. Watson College of Engineering and Applied Science, led a team that included PhD students Maryam Rezaie and Zahra Rafiee on .

鈥淭here are some regions in the small intestine that are not reachable, and that is why ingestible cameras have been developed to solve this issue,鈥 Choi said. 鈥淭hey can do many things, such as imaging and physical sensing, even drug delivery. The problem is power. So far, the electronics are using primary batteries that have a finite energy budget and cannot function for the long term.鈥

The Watson team鈥檚 solution builds on findings that Choi has made over the past decade about utilizing bacteria to create low levels of electricity that can power sensors and Wi-Fi connections as part of the Internet of Things.

Other options inside the small intestine are less viable: Traditional batteries are potentially harmful, wireless power transfer from outside the body is inefficient, temperature differences aren鈥檛 enough to harness thermal energy and intestinal movement is too slow for mechanical energy. Instead, Choi鈥檚 biobatteries utilize microbial fuel cells with spore-forming Bacillus subtilis bacteria that remain inert until they reach the small intestine.

鈥淗ow do you make your micro-fuel cell selectively work in the small intestine? We use a pH-sensitive membrane that requires certain conditions to activate,鈥 Choi said. 鈥淲hen you look at our gastrointestinal tract, the esophagus has a neutral pH, the same as the small intestine, but the transit time is only 10 seconds. It will not activate in this area, and it will never work in the stomach because the stomach has a very low pH. It only works in the small intestine.鈥

Choi knows that some people might balk at ingesting bacteria, but our bodies are filled with nontoxic microbes that help with digestion and other functions.

鈥淲e use these spores as a dormant, storable biocatalyst,鈥 he said. 鈥淭he spores can be germinated when the nutrients are available, and they can resume vegetative life and generate the power.鈥

Although this research has just been published, Choi and his students already are looking ahead to improving the capsule-sized biobatteries. Once the fuel cell reaches the small intestine, it takes up to an hour to germinate completely 鈥 faster would be better. The cell generates around 100 microwatts per square centimeter of power density 鈥 enough for wireless transmission, but 10 times more would offer many more options for use. The batteries also would require animal and human testing as well as biocompatibility studies.

Choi can foresee several uses that low-level microbial fuel cells could power, including biological and chemical sensors, drug-delivery systems and electrical stimulation devices.

鈥淚 believe that our micro-fuel cell has a huge potential, but we have a long way to go,鈥 he said.